In
a previous blog [1], I noted that there was no evidence in animals that endurobol
improved performance in animals. I must apologise as I missed a rather
important paper from Ron Evans group in 2008 that showed just that. The
performance effect was only seen if the mice were also doing exercise training
[2].
What
is interesting is the doses that were used in this study. The four-week program
of exercise training was paired with 5 mg/kg/day of the drug. This is at the low range of the long-term
(2 year) toxicity study done by Glaxo [3], which varied from 0 – 80 mg/kg/day.
But some adverse effects were still seen at the 5mg/kg/day level.
Interestingly one
anonymous commentator on my previous blog said that he/she knew people who have
been using it at a dosage of 10 mg per day for fat loss purposes and 20 mg per
day for a performance enhancing benefit. Indeed some companies are selling
pills of 5 mg size [4]. However, these doses are far lower than are shown to
work in the Evans paper (for an average 85 kg human, the “Evans” dose should be
425 mg/day - or three full bottles every
day of the pills that some manufacturers are selling.
The usual caveats
apply. There are long-term toxicity effects of this compound and it is
generally easier to show performance effects in laboratory rats and mice than
highly fit trained athletes.
- http://runswimthrowcheat.blogspot.co.uk/2014/02/gw501516-endurobol-and-doping-whats-all.htm
- Narkar VA, Downes M, Yu RT et al (2008) AMPK and PPARdelta agonists are exercise mimetics. Cell 134:405-415.
- Toxicological Sciences Volume 108, Number 1, March 2009 Abstracts # 895 and 896
- http://www.sarms-supply.com/gw501516-c-95.html
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